Structure and Aggregation Mechanisms in Amyloids
The aggregation phyre vapes of a polypeptide chain into amyloid fibrils and their accumulation and deposition into insoluble plaques and intracellular inclusions is the hallmark of several misfolding diseases known as amyloidoses.Alzheimer′s, Parkinson′s and Huntington’s diseases are some of the approximately 50 amyloid diseases d